2 edition of Post-translational regulation of nitric oxide production in insulin-secreting cells. found in the catalog.
Post-translational regulation of nitric oxide production in insulin-secreting cells.
Written in English
Thesis (Ph.D.) - University of Brighton, 2001.
|Contributions||University of Brighton. School of Pharmacy and Biomolecular Sciences.|
Chapter 4 Redox regulation of physiological processes 1 Cell signaling A Nitric oxide signaling B Carbon monoxide signaling C Superoxide and hydrogen peroxide D Other novel redox molecules 2 NO biochemistry A Characterization of the nitric oxide synthases B Regulation of nitric oxide synthases by intrinsic elements C Extrinsic regulation of nitric. Involvement of advanced lipooxidation end products (ALEs) and protein oxidation in the apoptotic actions of nitric oxide in insulin secreting RINm5F cells.
This review focuses attention upon recent accumulating evidence pointing to roles for nitric oxide induced post-translational modifications in the normal regulation as well Cited by: NO nitric oxide. NSP4 nonstructural the analysis of post-translational modifica- tions of Hsp60 revealed that SAHA treatment induced a modest reduction in the ubiq- uitination of the protein.
Insulin (from Latin insula, island) is a peptide hormone produced by beta cells of the pancreatic islets; it is considered to be the main anabolic hormone of the body. It regulates the metabolism of carbohydrates, fats and protein by promoting the absorption of carbohydrates, especially glucose from the blood into liver, fat and skeletal muscle cells. In these tissues the absorbed glucose is Aliases: INS, IDDM, IDDM1, IDDM2, ILPR, . Nitric oxide (NO) contributes to vessel homeostasis by inhibiting vascular smooth muscle contraction and growth, platelet aggregation, and leukocyte adhesion to the endothelium. Humans with atherosclerosis, diabetes, or hypertension often show impaired NO pathways. Nitric oxide (NO) is a mediator of vasodilation in blood vessels.
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In particular, nitric oxide (NO) is emerging as a central regulator of energy metabolism and body composition. NO bioavailability is decreased in animal models of diet-induced obesity and in obese and insulin resistant patients, and increasing NO output has remarkable effects on obesity and insulin erum-c.com by: Post-translational regulation of nitric oxide production in insulin-secreting cells.
Author: Stickings, Paul. ISNI: Awarding Body: University of Brighton Current Institution: University of Brighton Date of Award: Availability of Full Text. These make insulin secreting cells more vulnerable to serious damage than other cells by cytokines, cytotoxic nitric oxide radical and other reactive oxygen species.
To enhance the tolerance of insulin secreting cells against oxidative stress, genetic modification and Cited by: Oct 18, · Natali A, Ribeiro R, Baldi S et al () Systemic inhibition of nitric oxide synthesis in non-diabetic individuals produces a significant deterioration in glucose tolerance by increasing insulin clearance and inhibiting insulin erum-c.com by: 9.
Protection of insulin secreting cells from nitric oxide induced cellular damage by crosslinked hemoglobin. Abstract. Pancreatic islets and insulinoma cells are particularly vulnerable to serious damage by cytotoxic nitric oxide (NO) and/or oxidative stress, most probably due to their low expression levels of antioxidant enzymes.
The role of glucose levels in NO production is controversial; it has been reported that NOS activity and subsequently NO production are gradually increased due to an elevation in glucose concentrations within the pancreatic islets and cultured human aortic endothelial cells (HAECs).Author: Sevda Gheibi, Alan P.
Samsonov, Shahsanam Gheibi, Alexandra B. Vazquez, Khosrow Kashfi, Khosrow Kash. Nitric oxide (NO) as a signaling molecule involved in various physiological processes and abiotic/biotic stress responses in plants.
Nitric oxide (NO) can realize its biological functions directly by specific post‐translational modification of proteins and ion‐channel modulation or indirectly through the stimulation the activity of guanylyl cyclases (GCs) and activation of cyclic guanosine Author: L.V.
Dubovskaya, Y.S. Bakakina. Apr 21, · To address the mechanism of GK association with secretory granules, we examined the role of nitric oxide synthase in this regulation.
Neuronal nitric oxide synthase (nNOS) is activated by a rise in intracellular calcium, which is a known response of β cells to glucose or insulin stimulation (Aspinwall et al., ); and nNOS is also known to be localized on insulin secretory granules ( Cited by: Mar 30, · Nitric oxide (NO) in general plays a beneficial physiological role as a vasorelaxant and the role of NO is decided by its concentration present in physiological environments.
NO either facilitates cancer-promoting characters or act as an anti-cancer agent. The dilemma in Cited by: Post-translational regulation of NO synthase activity in the renal medulla of diabetic rats structures. In contrast, NOS3 is localized to plasma membrane caveolar domains and Golgi membranes in endothelial cells due to post-translational fatty Pollock JS.
NOS 3 subcellular localization in the regulation of nitric oxide production. Acta Cited by: Nitric oxide and its role in health and diabetes.
Nitric oxide (NO), is a free radical gas that is a powerful regulator of circulation (it is an endogenous vasodilator) and a neurotransmitter (it helps in the processing of nerve signals as they cross synapses). Jun 10, · Endothelial nitric oxide synthase (eNOS) is the nitric oxide synthase isoform responsible for maintaining systemic blood pressure, vascular Cited by: In line with the crucial homeostatic function of endothelial NO synthase (eNOS) and bioavailable nitric oxide (NO) for the vasculature, eNOS enzyme activity is subject of a delicate and interconnected system of various control erum-c.com by: Aug 01, · The effects of nitric oxide in biological systems depend on its steady-state concentration and where it is being produced.
The organ where nitric oxide is produced is relevant, and within the organ, which types of cells are actually contributing to this production seem to Cited by: Nitric oxide synthases (EC ) (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine.
NO is an important cellular signaling molecule. It helps modulate vascular tone, insulin secretion, airway tone, and peristalsis, and BRENDA: BRENDA entry. Panax notoginseng is a traditional medicinal herb in China. However, the high capacity of its roots to accumulate cadmium (Cd) poses a potential risk to human health.
Our previous study showed that nitrate reductase (NR)-dependent nitric oxide (NO) production promoted Cd accumulation in P. notoginseng root cell walls. In this study, the role of Mg in the regulation of NO production and Cd Author: Dongxu Li, Shuhui Xiao, Wen-Na Ma, Zhongping Peng, Dawood Khan, Qian Yang, Xinxun Wang, Xiangying Ko.
Extensive research work performed over the past decades has focused on understanding the role of nitric oxide (NO) in both promoting and preventing cancer.
The precise role of NO in tumor biology has been the cause of intense debate. Experimental evidences available in the literature highlight contrasting pro- and anti-tumor effects of erum-c.com by: 3. Nitric oxide and related nitrogen oxides have emerged as critical regulators of cell and tissue function.
The potency of NO was perhaps first realized after its inhalation by Sir Humphrey Davy, who nearly died from the self-experiment and after which he vowed to “never design again so rash an experiment” .Cited by: ().
Dual effect of nitric oxide on cytosolic Ca2 concentration and insulin secretion in rat pancreatic -cells. Effect of a glucokinase inhibitor on energy production and insulin release in pancreatic islets.
Exogenous nitric oxide and endogenous glucose-stimulated beta-cell nitric oxide augment insulin release. ().Author: Mark A. Rizzo and David W. Piston. Exogenous Nitric Oxide and Endogenous Glucose-Stimulated -Cell Nitric Oxide Augment Insulin Release Article (PDF Available) in Diabetes 51(12) · January with 39 Reads.
May 01, · The Role of IPP1 Is Regulation of the DDR by Nitric Oxide. The regulation of DDR signaling is controlled, in part, by the actions of protein phosphatases (24,48). Since the inhibitory actions of nitric oxide on DDR activation are selective for β-cells, the possibility that β-cells selectively express a phosphatase or pathway leading to Cited by: 3.Production, regulation and role of nitric oxide in glial cells V.
A. M. Vincent, F. J. H. Tilders and A-M. Van DamCA Research Institute Neurosciences Free University.Nitric oxide is a vital signalling molecule that controls blood flow and pressure. Unexpectedly, a redox switch in the protein haemoglobin α within endothelial cells regulates this molecule's Cited by: